Search results for "Genetics of aging"

showing 3 items of 3 documents

Interventions to Slow Aging in Humans: Are We Ready?

2015

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consens…

GerontologyAgingDisease onsetPrescription DrugsLongevityPsychological interventionReviewsBiologyAMP-Activated Protein KinasesGrowth hormoneAging; Anti-aging; Centenarians; Dietary restriction; Lifespan studies; Longevity gene; Longevity regulation; Cell Biology; AgingDietary interventionsBiological FactorsMicelongevity geneSettore BIO/13 - Biologia ApplicataAnimalsHumansSirtuinsProtein restrictionCentenarianInsulin-Like Growth Factor ILifespan studieCaloric RestrictionSettore MED/04 - Patologia GeneraleGeroscienceGene targetsRibosomal Protein S6 KinasesTOR Serine-Threonine Kinasesanti-agingdietary restrictionCell Biologydietary restriction ; lifespan studies ; longevity gene ; centenarians ; anti-aging ; longevity regulation ; aginglongevity regulation3. Good healthDietEnzyme ActivationGene Expression RegulationGrowth HormoneGenetics of agingcentenariansaging; anti-aging; centenarians; dietary restriction; lifespan studies; longevity gene; longevity regulationSignal Transductionlifespan studies
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Quantitative Genetics of the Aging of Reproductive Traits in the Houbara Bustard

2015

International audience; Do all traits within an organism age for the same reason? Evolutionary theories of aging share a common assumption: the strength of natural selection declines with age. A corollary is that additive genetic variance should increase with age. However, not all senescent traits display such increases suggesting that other mechanisms may be at play. Using longitudinal data collected from more than 5400 houbara bustards (Chlamydotis undulata) with an exhaustive recorded pedigree, we investigated the genetics of aging in one female reproductive trait (egg production) and three male reproductive traits (courtship display rate, ejaculate size and sperm viability), that displa…

0106 biological sciencesSenescenceMaleAgingScienceZoologyBiology010603 evolutionary biology01 natural sciencesBirdsSexual Behavior AnimalSemenGenetic variationAnimalsLongitudinal StudiesBustardGenetics[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyMultidisciplinaryNatural selectionCourtship displayModels GeneticReproductionQEndangered SpeciesRCourtshipGenetic VariationQuantitative geneticsbiology.organism_classificationClutch SizeSpermatozoa010601 ecologyMoroccoChlamydotis undulataGenetics of agingMedicineFemale[SDE.BE]Environmental Sciences/Biodiversity and EcologyResearch Article
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Acetic acid and acidification accelerate chronological and replicative aging in yeast

2012

Yeast is widely regarded as one of the most valuable model systems to study aging and particularly the genetics of aging. Researchers have established two different methods to study yeast aging known as the replicative lifespan (RLS) and the chronological lifespan (CLS). These have led to the identification of many mammalian genes that affect aging suggesting that they will continue to shed light on the fundamental biology of aging. In spite of the clear differences underpinning the mitotic cellular potential (RLS) and the survival in the non-dividing mode (CLS), the two models are clearly regulated by partly overlapping regulatory mechanism. This idea is supported by the observation that c…

Cell divisionCell BiologyCell cycleBiologySeptinProtein oxidationYeastBiochemistrySettore BIO/13 - Biologia ApplicataGenetics of agingaging yeast acidification free radicaoxydative damageSignal transductionMolecular BiologyMitosisDevelopmental BiologyCell Cycle
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